No, and no. Especially if it's with American actors. I think IÂ discussed this with a bunch of people in IRC, when we first heard about it. Some anorexic teen idol would play Sakura, Jesse Mc-whatever (that dude from Summerland? *shrug*) would play Syaoran, Fai would be just plain.... not pretty DX, and Kurogane would be either too old, or too caucasian.
I won't even begin to describe the horrible disaster that Mokona would be.
Since anime isn't exactly the hippest of hip, in comparisson to rap, for example, it'd be low budget, so it'd look ridiculously fake, as CGI is more expensive than a manga autographed by CLAMP. (note, I haven't confirmed this, so who knows. xD;;
The japanese might do a better job than us stupid Europeans and Americans, as it's based off of something extremely popular there. Then again, CGI is still expensive, and it could just turn into a series of cut-corners, similar to what seems to be happening to the TRC anime. ~_~