This is hard, but I chose Naruto and Gaara,
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because finding out that your whole village hates you because you have one of the nine tail demon within you. Then no really cares about you because of the demon. Sasuke past is really bad, but he is not like naruto and gaara. I feel more bad when reading about naruto and gaara, because even now when knowing about their past they are still being haunted by them (sasuke bro)
I put the reason withing the spoiler becasue I don't know how far every one read yet. I'm on chapter 302.